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ced5a5f5e9 Next Message. 2005;28:397-400. . PML protein isoforms and the RBCC/TRIM motif. SKIP enhances and SIRT1 represses the transcriptional activity of RAR To evaluate whether the RAR binding observed above is functionally relevant, we determined the effects of SIRT1 or SKIP on the transcriptional activity of RAR, using the RA-responsive RARE-luciferase reporter gene. View larger version: In this window In a new window Download as PowerPoint Slide Figure 3. Mol. Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein. S. Overall, our in vivo and in vitro assays revealed that SKIP forms a complex with SIRT1 and RAR at its low level but compete with SIRT1 for RAR binding at high level, suggesting that SKIP and SIRT1 may play reciprocal roles in regulating RAR activity.
The number of neurite-like structures counted per 1000 P19 cells was shown on each figure. Transfections were performed in the absence and presence of AtRA. Morphological analysis of PR CCR- and GCR-transduced cells revealed the presence of cells with immature features, compared with control cells clearly differentiated along the myeloid lineage (macrophages and granulocytes: Figure 3d). Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300. Cell Metab. Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia. (A) Ternary complex among RAR, SKIP and SIRT1.